NPY Y₁ receptor

NPY Y₁ receptor Related Products (21):

By Type:	Pan (6) Selective (7)
By Effects:	Inhibitor (1) Agonists (10) Antagonists (8) Modulator (1)

Cat. No.	Product Name	Effect	Purity

HY-107725

BIBO3304	Antagonist	99.96%
BIBO3304, a chemical probe, is a potent, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist, with subnanomolar affinity for both the human and the rat Y1 receptor (IC₅₀=0.38 and 0.72 nM, respectively).

HY-107726

BIBP3226 TFA	Antagonist	99.25%
BIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with K_is of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 TFA displays anxiogenic-like effect.

HY-P0208

[Leu31,Pro34]-Neuropeptide Y (porcine)	Agonist	99.39%
[Leu31,Pro34]- Neuropeptide Y (porcine), a Neuropeptide Y (NPY) analog, is a selective NPY Y1 receptor agonist. [Leu31,Pro34]- Neuropeptide Y (porcine) exhibits anxiolytic effects.

HY-107382

RF9	Antagonist	99.37%
RF9 is a potent and selective Neuropeptide FF receptor antagonist, with K_i values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.

HY-P1323A

[Leu31,Pro34]-Neuropeptide Y(human,rat,mouse) TFA	Agonist	98.05%
[Leu31,Pro34]-Neuropeptide Y(human,rat) TFA is a specific neuropeptide Y Y₁ receptor agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA slao activates Y₄, Y₅. [Leu31,Pro34]-Neuropeptide Y(human,rat) TFA can increase blood pressure in anesthetized rats and increases food intake.

HY-180406

NPY Y2 antagonist 2	Modulator
NPY Y2 antagonist 2 is a modulator targeting the neuropeptide Y (NPY) receptor Y2, with pK_i values of 6.8 nM and 7.2 nM in human and rat brains, respectively, and demonstrating blood-brain barrier penetration. NPY Y2 antagonist 2 shows selectivity for the Y1 and Y5 receptors. NPY Y2 antagonist 2 blocks the negative feedback regulation mediated by the NPY Y2 receptor, thereby increasing endogenous NPY release and enhancing Y1 receptor activation, resulting in the modulation of central neurotransmitter release. NPY Y2 antagonist 2 exhibits moderate in vivo clearance, high free fraction in rat brain, and a favorable brain/plasma ratio and brain exposure. NPY Y2 antagonist 2 is applicable for research in conditions such as mood disorders, anxiety induced by alcohol withdrawal, and social anxiety associated with nicotine withdrawal.

HY-120619

BMS-193885	Antagonist	99.91%
BMS-193885 is a selective neuropeptide Y1 receptor antagonist (K_i=3.3 nM) that competitively blocks the receptor to inhibit NPY-mediated appetite regulation signaling pathways, reduce food intake and inhibit weight gain. BMS-193885 has good blood-brain barrier penetration and is mainly used in the study of obesity and related metabolic diseases.

HY-107733

NTNCB hydrochloride	Antagonist	98.36%
NTNCB (Compound 11) hydrochloride is a potent and selective neuropeptide Y Y5 (NPY Y5) receptor antagonist with a K_i of 8 nM against human Y5.

HY-P1324

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide	Agonist	99.25%
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptide Y Y₅ receptor agonist with an IC₅₀ of 0.24 nM for binding to the hY₅ receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake.

HY-P3877A

(Leu31,Pro34)-Peptide YY (human) TFA	Agonist	98.63%
(Leu31,Pro34)-Peptide YY (human) (TFA) is the TFA form of (Leu31,Pro34)-Peptide YY (human) (HY-P3877). (Leu31,Pro34)-Peptide YY (human) (TFA) is a Peptide YY (HY-P1514) derivative and is a potent and selective Y₁ agonist with a K_D of 1.0 nM.

HY-107382A

RF9 hydrochloride	Antagonist	99.91%
RF9 hydrochloride is a potent and selective Neuropeptide FF receptor antagonist, with K_i values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.

HY-P3877

(Leu31,Pro34)-Peptide YY (human)	Agonist
(Leu31,Pro34)-Peptide YY (human) is a Peptide YY (HY-P1514) derivative and is a potent and selective Y₁ agonist with a K_D of 1.0 nM.

HY-P11043

GEP44	Inhibitor
GEP44 is a peptide biased triple agonist targeting Glucagon-like peptide 1 receptor (GLP-1R), neuropeptide Y1 Receptor (Y1-R), and neuropeptide Y2 Receptor (Y2-R). GEP44 induces Y1-R antagonist-controlled, GLP-1R-dependent stimulation of insulin secretion in both rat and human pancreatic islets by counteracting effects of Y1-R and GLP-1R agonism. GEP44 promotes insulin-independent Y1-R-mediated glucose uptake in muscle tissue and significantly reduces food intake and body weight in diet-induced obese rat models. GEP44 can be used for obesity and type 2 diabetes mellitus research.

HY-145837

Y1R probe-1
Y1R probe-1 (Compound 39) is a high-affinity fluorescence probe for the Neuropeptide Y Y1 Receptor. Y1R probe-1 has the potential for the research of cancer disease.

HY-P1323

[Leu31,Pro34]-Neuropeptide Y (human,rat)	Agonist
[Leu31,Pro34]-Neuropeptide Y(human,rat) is a specific neuropeptide Y Y₁ receptor agonist. [Leu31,Pro34]-Neuropeptide Y(human,rat) slao activates Y₄, Y₅. [Leu31,Pro34]-Neuropeptide Y(human,rat) can increase blood pressure in anesthetized rats and increases food intake.

HY-P0198B

[D-Arg25]-Neuropeptide Y (human)	Agonist
[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY) is a Y₁ receptor selective agonist. Neuropeptide Y (human) is involved in Alzheimer's disease (AD) and protects rat cortical neurons against β-Amyloid toxicity.

HY-P1325

BWX 46	Agonist
BWX 46 (((Cys31, Nva 34)-Neuropeptide Y (27-36))2) is a selective Y₅ receptor agonist with an IC₅₀ value of 0.85 nM. BWX 46 can inhibit the synthesis of cAMP in Y₅ cells.

HY-P3876

(Pro34)-Peptide YY (human)	Agonist
(Pro34)-Peptide YY (human) is a highly Y₁-selective full agonist of Peptide YY (HY-P1514)/neuropeptide Y receptors.

HY-P1324A

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic polypeptide TFA	Agonist
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptide Y Y₅ receptor agonist with an IC₅₀ of 0.24 nM for binding to the hY₅ receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake.

HY-144603

Neuropeptide Y Y1 receptor antagonist 1	Antagonist
Neuropeptide Y Y1 receptor antagonist 1 (compound 39), a fluorescent probe, is a potent antagonist of neuropeptide Y Y¹ receptor (Y¹R), with a K_i of 0.19 nM.

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